GW-0742
GW-0742 is a mixed PPAR-B agonist antagonist, dose dependent. It also has weak activity at multiple nuclear receptors.
It is antagonistic to androgen receptors and VDR. In silico modeling suggests it has effects on thyroid hormone receptors.
GW0742 has been shown to ameliorate experimentally induced pancreatitis in mice. It also prevents hypertension in diet-induced obese mice. and is also being investigated as a potential antidiabetic agent. It is also an anti-inflammatory agent.
Concentration
20mg/ml.
half-life
24 hours.
DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or domestic use. Please familiarize yourself with our DISCLAIMER before ordering.
Included is a precision pipette marked per 0.2 ml!
Shake well before use.
Data sheet
GW-0742 – Solution, 600mg (20mg/mL)
| Application | Potent PPARβ and PPARδ agonist |
| CAS | 317318-84-6 |
| Molar Mass | 471.5 g/mol |
| Chemical Formula | C21H17F4NO3S2 |
| IUPAC Name | 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid |
| Synonyms | GW0742, 317318-84-6, GW 0742, GW-0742, GW0742X, GW610742, GW-0742X, CHEMBL38508, CHEBI:79991, {4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]-4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic Acid, SR-05000000447, 3tkm, GW 0742X, GWdelta 0742, GW 610742, GW-610742, DSSTox_CID_20760, DSSTox_RID_79591, DSSTox_GSID_40760, MLS006011159 |
| Storage | Store at room temperature, tightly sealed, away from heat, light and moisture. |
| Solubility | Soluble in DMSO, PEG 400 |
| Organoleptic Profile | Clear liquid |
| Physical Form | Solution in PEG 400 |
| Specification | 20mg/mL ±5% |
| Terms | This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering. |